(R)-CR8 (trihydrochloride), CAS [[1786438-30-9]]

Product Overview

• Article Name: (R)-CR8 (trihydrochloride), CAS [[1786438-30-9]]
• Biozol Catalog Number: MCE-HY-18340A
• Supplier Catalog Number: HY-18340A
• Alternative Catalog Number: MCE-HY-18340A-50MG,MCE-HY-18340A-25MG,MCE-HY-18340A-10MMX1ML,MCE-HY-18340A-10MG,MCE-HY-18340A-100MG,MCE-HY-18340A-5MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: CR8, (R)-Isomer (trihydrochloride)

Product Description

(R)-CR8 (CR8) trihydrochloride, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC50=0.09 µM), CDK2/cyclin A (0.072 µM), CDK2/cyclin E (0.041 µM), CDK5/p25 (0.11 µM), CDK7/cyclin H (1.1 µM), CDK9/cyclin T (0.18 µM) and CK1delta/epsilon (0.4 µM). (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect[1][2]. (R)-CR8 trihydrochloride acts as a molecular glue degrader that depletes cyclin K[3].

Product Properties

• Molecular Weight: 540.92
• Purity: 99.37
• CAS Number: [1786438-30-9]
• Formula: C24H32Cl3N7O
• Target: Apoptosis,CDK,Molecular Glues

Application Notes

• Application Notes: MCE Product type: Reference compound