T-10531 is a selective USP25/USP28 inhibitor. T-10531 exhibits an IC50 of 0.03 µM and a Kd of 0.2 µM against human USP25, as well as an IC50 of 0.12 µM and a Kd of 0.06 µM against human USP28. T-10531 inhibits USP25/USP28 activity and induces the degradation of USP25 via the proteasomal pathway, without inhibiting other deubiquitinases. T-10531 can be used in the research of squamous cell carcinoma, colorectal cancer, gastric cancer, triple-negative breast cancer and pancreatic cancer[1].
Molekulargewicht:
665.88
Formel:
C26H22BrClF4N2O5S
Target-Kategorie:
Deubiquitinase
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
