T-10531 is a selective USP25/USP28 inhibitor. T-10531 exhibits an IC50 of 0.03 µM and a Kd of 0.2 µM against human USP25, as well as an IC50 of 0.12 µM and a Kd of 0.06 µM against human USP28. T-10531 inhibits USP25/USP28 activity and induces the degradation of USP25 via the proteasomal pathway, without inhibiting other deubiquitinases. T-10531 can be used in the research of squamous cell carcinoma, colorectal cancer, gastric cancer, triple-negative breast cancer and pancreatic cancer[1].
Molecular Weight:
665.88
Formula:
C26H22BrClF4N2O5S
Target:
Deubiquitinase
Application Notes:
MCE Product type: Reference compound
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