C5F2-HCB is a CYP-mediated inhibitor of the biosynthesis of arachidonic acid epoxygenase product () 14,15-EET (HY-150084), with an IC50 of 3.1 µM. C5F2-HCB inhibits EET-driven oxidative phosphorylation (OXPHOS) associated with tumor hypoxia, converting an immunologically cold tumor microenvironment into a hot one. C5F2-HCB reverses the immune-excluded tumor microenvironment in ER+HER2- breast cancer allograft models. C5F2-HCB can be used in research related to ER+HER2- breast cancer[1].
Molekulargewicht:
337.41
CAS Nummer:
[2792206-44-9]
Formel:
C17H25F2N5
Target-Kategorie:
Cytochrome P450,Oxidative Phosphorylation
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
