C5F2-HCB is a CYP-mediated inhibitor of the biosynthesis of arachidonic acid epoxygenase product () 14,15-EET (HY-150084), with an IC50 of 3.1 µM. C5F2-HCB inhibits EET-driven oxidative phosphorylation (OXPHOS) associated with tumor hypoxia, converting an immunologically cold tumor microenvironment into a hot one. C5F2-HCB reverses the immune-excluded tumor microenvironment in ER+HER2- breast cancer allograft models. C5F2-HCB can be used in research related to ER+HER2- breast cancer[1].
Molecular Weight:
337.41
CAS Number:
[2792206-44-9]
Formula:
C17H25F2N5
Target:
Cytochrome P450,Oxidative Phosphorylation
Application Notes:
MCE Product type: Reference compound
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