MTXPG5 is a long-chain Methotrexate (HY-14519) metabolite and thymidylate synthase inhibitor with a Ki of 0.047 µM. MTXPG5 inhibits 5-aminoimidazole-4-carboxamide ribonucleotide transformylase, interferes with DNA synthesis and immune cell proliferation, and inhibits pro-inflammatory cytokine production via extracellular adenosine accumulation and elevated cAMP levels. MTXPG5 can be used for the research of leukaemia and rheumatoid arthritis[1][2][3].
Molekulargewicht:
970.91
CAS Nummer:
[80801-54-3]
Formel:
C40H50N12O17
Target-Kategorie:
Thymidylate Synthase
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
