MTXPG5 is a long-chain Methotrexate (HY-14519) metabolite and thymidylate synthase inhibitor with a Ki of 0.047 µM. MTXPG5 inhibits 5-aminoimidazole-4-carboxamide ribonucleotide transformylase, interferes with DNA synthesis and immune cell proliferation, and inhibits pro-inflammatory cytokine production via extracellular adenosine accumulation and elevated cAMP levels. MTXPG5 can be used for the research of leukaemia and rheumatoid arthritis[1][2][3].
Molecular Weight:
970.91
CAS Number:
[80801-54-3]
Formula:
C40H50N12O17
Target:
Thymidylate Synthase
Application Notes:
MCE Product type: Reference compound
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