PROTAC CDK2-pRb degrader-1, CAS [[3030276-48-0]] Preis auf Anfrage

Produktübersicht

• Artikelname: PROTAC CDK2-pRb degrader-1, CAS [[3030276-48-0]] Preis auf Anfrage
• Artikelnummer: MCE-HY-186132
• Hersteller Artikelnummer: HY-186132
• Alternativnummer: MCE-HY-186132-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PROTAC CDK2-pRb degrader-1 is an orally active PROTAC-class degrader of CDK2. PROTAC CDK2-pRb degrader-1 effectively inhibits the phosphorylation of retinoblastoma protein (Rb) at serine residues 807/811 by inducing ubiquitination and proteasomal degradation of CDK2. PROTAC CDK2-pRb degrader-1 exhibits significant activity against human cells (with EC50 values of 12 nM and 125 nM, respectively). In xenograft models, PROTAC CDK2-pRb degrader-1 effectively inhibits tumor growth and induces tumor stasis, making it suitable for research related to CCNE1-amplified cancers (such as ovarian cancer, gastric cancer, and breast cancer)[1].

Produkteigenschaften

• Molekulargewicht: 830.93
• CAS Nummer: [3030276-48-0]
• Formel: C40H50F4N8O5S
• Target-Kategorie: CDK,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound