PROTAC CDK2-pRb degrader-1, CAS [[3030276-48-0]] Preis auf Anfrage

Product Overview

• Article Name: PROTAC CDK2-pRb degrader-1, CAS [[3030276-48-0]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-186132
• Supplier Catalog Number: HY-186132
• Alternative Catalog Number: MCE-HY-186132-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

PROTAC CDK2-pRb degrader-1 is an orally active PROTAC-class degrader of CDK2. PROTAC CDK2-pRb degrader-1 effectively inhibits the phosphorylation of retinoblastoma protein (Rb) at serine residues 807/811 by inducing ubiquitination and proteasomal degradation of CDK2. PROTAC CDK2-pRb degrader-1 exhibits significant activity against human cells (with EC50 values of 12 nM and 125 nM, respectively). In xenograft models, PROTAC CDK2-pRb degrader-1 effectively inhibits tumor growth and induces tumor stasis, making it suitable for research related to CCNE1-amplified cancers (such as ovarian cancer, gastric cancer, and breast cancer)[1].

Product Properties

• Molecular Weight: 830.93
• CAS Number: [3030276-48-0]
• Formula: C40H50F4N8O5S
• Target: CDK,PROTACs

Application Notes

• Application Notes: MCE Product type: Reference compound