Avutometinib (potassium), CAS [[946128-90-1]] Preis auf Anfrage

Produktübersicht

• Artikelname: Avutometinib (potassium), CAS [[946128-90-1]] Preis auf Anfrage
• Artikelnummer: MCE-HY-18652A
• Hersteller Artikelnummer: HY-18652A
• Alternativnummer: MCE-HY-18652A-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: Ro 5126766 (potassium), CH5126766 (potassium)

Produktbeschreibung

Avutometinib (CH5126766) (potassium) is a RAF/MEK clamp that potently inhibits RAF/MEK kinase activity and induces dominant negative RAF-MEK complexes preventing phosphorylation of MEK by ARAF, BRAF and CRAF. Avutometinib (potassium) shows anti-proliferative potency across tumor cell lines carrying KRAS mutations including PDAC cell lines. Avutometinib (potassium) induces tumor inhibition and increases survival in a KRAS/p53 pancreatic cancer mouse model. Avutometinib (potassium) is promising for research of low-grade-serous-ovarian-carcinoma (LGSOC), ovarian cancer and pancreatic ductal adenocarcinoma (PDAC)[1][2].

Produkteigenschaften

• Molekulargewicht: 510.56
• CAS Nummer: [946128-90-1]
• Formel: C21H18FKN5O5S
• Target-Kategorie: MEK,Raf

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound