Avutometinib (potassium), CAS [[946128-90-1]] Preis auf Anfrage

Product Overview

• Article Name: Avutometinib (potassium), CAS [[946128-90-1]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-18652A
• Supplier Catalog Number: HY-18652A
• Alternative Catalog Number: MCE-HY-18652A-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: Ro 5126766 (potassium), CH5126766 (potassium)

Product Description

Avutometinib (CH5126766) (potassium) is a RAF/MEK clamp that potently inhibits RAF/MEK kinase activity and induces dominant negative RAF-MEK complexes preventing phosphorylation of MEK by ARAF, BRAF and CRAF. Avutometinib (potassium) shows anti-proliferative potency across tumor cell lines carrying KRAS mutations including PDAC cell lines. Avutometinib (potassium) induces tumor inhibition and increases survival in a KRAS/p53 pancreatic cancer mouse model. Avutometinib (potassium) is promising for research of low-grade-serous-ovarian-carcinoma (LGSOC), ovarian cancer and pancreatic ductal adenocarcinoma (PDAC)[1][2].

Product Properties

• Molecular Weight: 510.56
• CAS Number: [946128-90-1]
• Formula: C21H18FKN5O5S
• Target: MEK,Raf

Application Notes

• Application Notes: MCE Product type: Reference compound