AMG-337, CAS [[1173699-31-4]]

Produktübersicht

• Artikelname: AMG-337, CAS [[1173699-31-4]]
• Artikelnummer: MCE-HY-18696
• Hersteller Artikelnummer: HY-18696
• Alternativnummer: MCE-HY-18696-50MG,MCE-HY-18696-100MG,MCE-HY-18696-25MG,MCE-HY-18696-10MMX1ML,MCE-HY-18696-10MG,MCE-HY-18696-200MG,MCE-HY-18696-5MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

AMG-337 is a potent, orally active, selective MET kinase inhibitor with IC50 values of 1, 1, 4.7, 5, 21.5, 1077 and >4000 nM of WT MET, H1094R MET, M1250T MET, HGF-stimulated pMET (PC3 cells) MET, V1092I MET, Y1230H MET, and D1228H MET, respectively. AMG 337 inhibits the phosphorylation of MET and downstream effectors in MET-amplified cancer cell lines, resulting in an inhibition of MET-dependent cell proliferation and induction of apoptosis[1][2].

Produkteigenschaften

• Molekulargewicht: 463.46
• Reinheit: 99.40
• CAS Nummer: [1173699-31-4]
• Formel: C23H22FN7O3
• Target-Kategorie: Apoptosis,Caspase,c-Met/HGFR

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound