AMG-337 is a potent, orally active, selective MET kinase inhibitor with IC50 values of 1, 1, 4.7, 5, 21.5, 1077 and >4000 nM of WT MET, H1094R MET, M1250T MET, HGF-stimulated pMET (PC3 cells) MET, V1092I MET, Y1230H MET, and D1228H MET, respectively. AMG 337 inhibits the phosphorylation of MET and downstream effectors in MET-amplified cancer cell lines, resulting in an inhibition of MET-dependent cell proliferation and induction of apoptosis[1][2].
Molecular Weight:
463.46
Purity:
99.40
CAS Number:
[1173699-31-4]
Formula:
C23H22FN7O3
Target:
Apoptosis,Caspase,c-Met/HGFR
Application Notes:
MCE Product type: Reference compound
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