Cilobradine, CAS [[147541-45-5]] Preis auf Anfrage

Produktübersicht

• Artikelname: Cilobradine, CAS [[147541-45-5]] Preis auf Anfrage
• Artikelnummer: MCE-HY-18940
• Hersteller Artikelnummer: HY-18940
• Alternativnummer: MCE-HY-18940-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: Cilo

Produktbeschreibung

Cilobradine (Cilo) is a HCN channel blocker with heart rate reducing activity. Cilobradine blocks the slow inward current of human HCN1, HCN2, HCN3, and HCN4 channels. Cilobradine has a slightly higher efficiency in blocking endogenous If in mouse sinoatrial node cells (IC50 value is 0.62µM). Cilobradine can dose-dependently reduce the heart rate from 600 to 200 bpm with an ED50 value of 1.2 mg/kg. Cilobradine induces arrhythmias at doses greater than 5 mg/kg, which are characterized by periodic fluctuations between T waves and P waves[1].

Produkteigenschaften

• Molekulargewicht: 482.61
• CAS Nummer: [147541-45-5]
• Formel: C28H38N2O5
• Target-Kategorie: Endogenous Metabolite

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound