Cilobradine, CAS [[147541-45-5]] Preis auf Anfrage

Product Overview

• Article Name: Cilobradine, CAS [[147541-45-5]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-18940
• Supplier Catalog Number: HY-18940
• Alternative Catalog Number: MCE-HY-18940-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: Cilo

Product Description

Cilobradine (Cilo) is a HCN channel blocker with heart rate reducing activity. Cilobradine blocks the slow inward current of human HCN1, HCN2, HCN3, and HCN4 channels. Cilobradine has a slightly higher efficiency in blocking endogenous If in mouse sinoatrial node cells (IC50 value is 0.62µM). Cilobradine can dose-dependently reduce the heart rate from 600 to 200 bpm with an ED50 value of 1.2 mg/kg. Cilobradine induces arrhythmias at doses greater than 5 mg/kg, which are characterized by periodic fluctuations between T waves and P waves[1].

Product Properties

• Molecular Weight: 482.61
• CAS Number: [147541-45-5]
• Formula: C28H38N2O5
• Target: Endogenous Metabolite

Application Notes

• Application Notes: MCE Product type: Reference compound