Ketodarolutamide-d3, CAS [[2484757-41-5]] Preis auf Anfrage

Produktübersicht

• Artikelname: Ketodarolutamide-d3, CAS [[2484757-41-5]] Preis auf Anfrage
• Artikelnummer: MCE-HY-19337S
• Hersteller Artikelnummer: HY-19337S
• Alternativnummer: MCE-HY-19337S-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: BAY 1896953-d3, ORM-15341-d3

Produktbeschreibung

Ketodarolutamide-d3 (BAY 1896953-d3) is the deuterium labeled Ketodarolutamide (HY-19337). Ketodarolutamide (ORM-15341) is a potent, high-affinity nonsteroidal competitive full antagonist of androgen receptor (AR). Ketodarolutamide displays a Ki value of 8 nM for rat wild-type AR and an IC50 value of 38 nM in AR-HEK293 cells[1]. Ketodarolutamide inhibits testosterone-induced nuclear translocation of the AR and antagonizes both overexpressed and mutant ARs[1]. Ketodarolutamide specifically suppresses the proliferation of AR-dependent prostate cancer cells and exhibits antitumor activity in models of castration-resistant prostate cancer (CRPC) [1][2]. Ketodarolutamide is suitable for the mechanistic and therapeutic research of prostate cancer[1][2].

Produkteigenschaften

• Molekulargewicht: 399.85
• CAS Nummer: [2484757-41-5]
• Formel: C19H14D3ClN6O2
• Target-Kategorie: Androgen Receptor,Isotope-Labeled Compounds

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Isotope-Labeled Compounds