Ketodarolutamide-d3, CAS [[2484757-41-5]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-19337S
Supplier Catalog Number:
HY-19337S
Alternative Catalog Number:
MCE-HY-19337S-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
BAY 1896953-d3, ORM-15341-d3
Ketodarolutamide-d3 (BAY 1896953-d3) is the deuterium labeled Ketodarolutamide (HY-19337). Ketodarolutamide (ORM-15341) is a potent, high-affinity nonsteroidal competitive full antagonist of androgen receptor (AR). Ketodarolutamide displays a Ki value of 8 nM for rat wild-type AR and an IC50 value of 38 nM in AR-HEK293 cells[1]. Ketodarolutamide inhibits testosterone-induced nuclear translocation of the AR and antagonizes both overexpressed and mutant ARs[1]. Ketodarolutamide specifically suppresses the proliferation of AR-dependent prostate cancer cells and exhibits antitumor activity in models of castration-resistant prostate cancer (CRPC) [1][2]. Ketodarolutamide is suitable for the mechanistic and therapeutic research of prostate cancer[1][2].
Molecular Weight:
399.85
CAS Number:
[2484757-41-5]
Formula:
C19H14D3ClN6O2
Target:
Androgen Receptor,Isotope-Labeled Compounds
Application Notes:
MCE Product type: Isotope-Labeled Compounds
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