ML289 (VU0463597) is a potent, selective, and CNS-penetrant mGlu3 (IC50=0.66 µM) negative allosteric modulator. ML289 displays >15-fold selectivity over mGlu2 and is inactive against mGlu5[1]. ML289 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Molekulargewicht:
349.42
Reinheit:
98.29
CAS Nummer:
[1382481-79-9]
Formel:
C22H23NO3
Target-Kategorie:
mGluR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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