ML289 (VU0463597) is a potent, selective, and CNS-penetrant mGlu3 (IC50=0.66 µM) negative allosteric modulator. ML289 displays >15-fold selectivity over mGlu2 and is inactive against mGlu5[1]. ML289 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Molecular Weight:
349.42
Purity:
98.29
CAS Number:
[1382481-79-9]
Formula:
C22H23NO3
Target:
mGluR
Application Notes:
MCE Product type: Reference compound
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