BMS-561392 formate (DPC 333 formate) is a selective ADAM17(TACE) inhibitor. BMS-561392 formate inhibits TNF-alpha secretion by regulating signaling pathways such as p44 MAPK and NF-kappaB. BMS-561392 formate also affects the survival of central nervous system-related cells including oligodendrocytes and microglia. BMS-561392 formate promotes microglial apoptosis, enlarges the injury area and exacerbates astrogliosis in a mouse spinal cord injury model. BMS-561392 formate can be used in research related to spinal cord injury and inflammatory diseases[1][2].
Molekulargewicht:
522.59
Reinheit:
99.13
CAS Nummer:
[2922280-85-9]
Formel:
C28H34N4O6
Target-Kategorie:
Apoptosis,NF-kappaB,p38 MAPK,TNF Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound1
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten