T6167923 is a selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-kappaB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC50s of 2.7 µM, 2.9 µM, 2.66 µM and 2.66 µM for IFN-gamma, IL-1beta, IL-6 and TNF-alpha, respectively[1][2].
Molekulargewicht:
458.39
Reinheit:
99.40
CAS Nummer:
[2437475-16-4]
Formel:
C17H20BrN3O3S2
Target-Kategorie:
MyD88
Anwendungsbeschreibung:
Reference compound
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