T6167923 is a selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-kappaB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC50s of 2.7 µM, 2.9 µM, 2.66 µM and 2.66 µM for IFN-gamma, IL-1beta, IL-6 and TNF-alpha, respectively[1][2].
Molecular Weight:
458.39
Purity:
99.40
CAS Number:
[2437475-16-4]
Formula:
C17H20BrN3O3S2
Target:
MyD88
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted