(-)-JJ-450, CAS [[1998094-23-7]] Preis auf Anfrage

Produktübersicht

• Artikelname: (-)-JJ-450, CAS [[1998094-23-7]] Preis auf Anfrage
• Artikelnummer: MCE-HY-403733A
• Hersteller Artikelnummer: HY-403733A
• Alternativnummer: MCE-HY-403733A-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

(-)-JJ-450 is a non-competitive antagonist targeting the androgen receptor (AR). (-)-JJ-450 is more potent than (+)-JJ-450 (HY-403733B) in inhibiting androgen-induced AR activity, and the mechanism of AR inhibition by (+)-JJ-450 is different from that of Enzalutamide (MDV3100) (HY-70003), which may target the ligand binding domain (LBD) of AR. (-)-JJ-450 inhibits the transcriptional activity of wild-type AR and mutant ARF876L by inhibiting AR nuclear translocation and promoting nuclear degradation of unbound AR. (-)-JJ-450 can be used in the study of castration-resistant prostate cancer (CRPC) resistant to Enzalutamide[1].

Produkteigenschaften

• Molekulargewicht: 372.86
• CAS Nummer: [1998094-23-7]
• Formel: C21H22ClFN2O
• Target-Kategorie: Androgen Receptor

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound