(-)-JJ-450, CAS [[1998094-23-7]] Preis auf Anfrage

Product Overview

• Article Name: (-)-JJ-450, CAS [[1998094-23-7]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-403733A
• Supplier Catalog Number: HY-403733A
• Alternative Catalog Number: MCE-HY-403733A-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

(-)-JJ-450 is a non-competitive antagonist targeting the androgen receptor (AR). (-)-JJ-450 is more potent than (+)-JJ-450 (HY-403733B) in inhibiting androgen-induced AR activity, and the mechanism of AR inhibition by (+)-JJ-450 is different from that of Enzalutamide (MDV3100) (HY-70003), which may target the ligand binding domain (LBD) of AR. (-)-JJ-450 inhibits the transcriptional activity of wild-type AR and mutant ARF876L by inhibiting AR nuclear translocation and promoting nuclear degradation of unbound AR. (-)-JJ-450 can be used in the study of castration-resistant prostate cancer (CRPC) resistant to Enzalutamide[1].

Product Properties

• Molecular Weight: 372.86
• CAS Number: [1998094-23-7]
• Formula: C21H22ClFN2O
• Target: Androgen Receptor

Application Notes

• Application Notes: MCE Product type: Reference compound