Lestaurtinib (CEP-701) is an orally active and selective RPTKs (receptor protein tyrosine kinase) inhibitor, competitively inhibits ATP binding to the TrkA/B/C domain. Lestaurtinib inhibits RPTKs phosphorylation, with IC50s of 2, 25 and 0.9 nM for FLT3, TrkA and JAK2, respectively. Lestaurtinib induces apoptosis and cycle arrest, also can inhibit growth of tumor[1][2][3][4][5][6].
Molekulargewicht:
439.46
Reinheit:
99.66
CAS Nummer:
[111358-88-4]
Formel:
C26H21N3O4
Target-Kategorie:
Apoptosis,FLT3,JAK,STAT,Trk Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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