Lestaurtinib (CEP-701) is an orally active and selective RPTKs (receptor protein tyrosine kinase) inhibitor, competitively inhibits ATP binding to the TrkA/B/C domain. Lestaurtinib inhibits RPTKs phosphorylation, with IC50s of 2, 25 and 0.9 nM for FLT3, TrkA and JAK2, respectively. Lestaurtinib induces apoptosis and cycle arrest, also can inhibit growth of tumor[1][2][3][4][5][6].
Molecular Weight:
439.46
Purity:
99.66
CAS Number:
[111358-88-4]
Formula:
C26H21N3O4
Target:
Apoptosis,FLT3,JAK,STAT,Trk Receptor
Application Notes:
MCE Product type: Reference compound
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