Daporinad (hydrochloride), CAS [[2727965-45-7]] Preis auf Anfrage

Produktübersicht

• Artikelname: Daporinad (hydrochloride), CAS [[2727965-45-7]] Preis auf Anfrage
• Artikelnummer: MCE-HY-50876A
• Hersteller Artikelnummer: HY-50876A
• Alternativnummer: MCE-HY-50876A-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: FK866 (hydrochloride), APO866 (hydrochloride)

Produktbeschreibung

Daporinad (FK866) hydrochloride is a non-competitive inhibitor of nicotinamide phosphoribosyltransferase (Nampt), with a Ki value of 0.3 nM. Daporinad hydrochloride depletes NAD+ and ATP levels, inhibits mTORC1 and MAPK/ERK pathways, and activates TFEB to induce autophagy. Daporinad hydrochloride causes the depletion of the endoplasmic reticulum Ca pool, ultimately weakening the mitogen-induced Ca signal and the activation and function of T cells. Daporinad hydrochloride induces cell cycle arrest and apoptosis, and inhibits cell proliferation. Daporinad hydrochloride can be used for the study of myeloma, liver cancer, and immunosuppression[1][2][3][4].

Produkteigenschaften

• Molekulargewicht: 427.97
• CAS Nummer: [2727965-45-7]
• Formel: C24H30ClN3O2
• Target-Kategorie: Apoptosis,Autophagy,ERK,mTOR,NAMPT,p38 MAPK

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound