A-582941 dihydrochloride is a selective, orally active, blood-brain barrier-permeable alpha7 nAChR agonist, with Ki values of 10.8 nM and 17 nM in rat brain and human frontal cortex, respectively. A-582941 dihydrochloride exhibits agonistic activity at 5-HT3 receptors, with a Ki of 150 nM. A-582941 dihydrochloride triggers phosphorylation of ERK1/2 and CREB, inhibits GSK-3beta via Ser-9 phosphorylation, increases acetylcholine release, induces the expression of Arc and c-Fos, activates brain regions associated with working memory and attention, and reduces cell death caused by nerve growth factor (NGF) deprivation. A-582941 dihydrochloride is applicable for the research of Alzheimers disease and schizophrenia[1][2][3].
Molekulargewicht:
353.29
Reinheit:
99.78
CAS Nummer:
[848591-90-2]
Formel:
C17H22Cl2N4
Target-Kategorie:
5-HT Receptor,Epigenetic Reader Domain,ERK,nAChR
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
