MNS (NSC 170724), the beta-nitrostyrene derivative, is an orally active tyrosine kinase inhibitor and a broad-spectrum antiplatelet agent. MNS inhibits Src, Syk, and FAK with IC50 of 27.3, 2.8, and 97.6 µM, respectively. MNS inhibits NLRP3 inflammasome and beta1 integrin. MNS completely inhibits U46619, ADP-, arachidonic acid-, collagen-, and thrombin-induced platelet aggregation with IC50 values of 2.1, 4.1, 5.8, 7.0, and 12.7 µM, respectively. MNS is cytotoxic to a variety of cells[1][2][3][4][5][6][7][8][9].
Molekulargewicht:
193.16
Reinheit:
99.60
CAS Nummer:
[1485-00-3]
Formel:
C9H7NO4
Target-Kategorie:
Integrin,NOD-like Receptor (NLR),Src,Syk
Anwendungsbeschreibung:
MCE Product type: Reference compound
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