Irsogladine (maleate), CAS [[84504-69-8]] Preis auf Anfrage

Produktübersicht

• Artikelname: Irsogladine (maleate), CAS [[84504-69-8]] Preis auf Anfrage
• Artikelnummer: MCE-HY-B0327A
• Hersteller Artikelnummer: HY-B0327A
• Alternativnummer: MCE-HY-B0327A-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: Dicloguamine maleate, MN1695

Produktbeschreibung

Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. Target: PDE4, mACHR Irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (P < 0.02, P < 0.001), in tPA-deficient mice by 42.6 and 46% (P < 0.001, P < 0.001), and in uPA-deficient mice by 27.2 and 46% (P < 0.05, p < 0.001), respectively. Irsogladine inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout mice [1]. Irsogladine up-regulates GJIC between PC cells via regulation of the PKA pathway. It also suggests a useful adjuvant of Irsogladine to pancreatic cancer therapy [2]. irsogladine produces the increase of intracellular cAMP content via non-selective inhibition of PDE isozymes, which may be a key mechanism involved in its gastroprotective actions [3].

Produkteigenschaften

• Molekulargewicht: 372.16
• CAS Nummer: [84504-69-8]
• Formel: C13H11Cl2N5O4
• Target-Kategorie: mAChR,Phosphodiesterase (PDE)

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound