Irsogladine (maleate), CAS [[84504-69-8]] Preis auf Anfrage

Product Overview

• Article Name: Irsogladine (maleate), CAS [[84504-69-8]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-B0327A
• Supplier Catalog Number: HY-B0327A
• Alternative Catalog Number: MCE-HY-B0327A-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: Dicloguamine maleate, MN1695

Product Description

Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. Target: PDE4, mACHR Irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (P < 0.02, P < 0.001), in tPA-deficient mice by 42.6 and 46% (P < 0.001, P < 0.001), and in uPA-deficient mice by 27.2 and 46% (P < 0.05, p < 0.001), respectively. Irsogladine inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout mice [1]. Irsogladine up-regulates GJIC between PC cells via regulation of the PKA pathway. It also suggests a useful adjuvant of Irsogladine to pancreatic cancer therapy [2]. irsogladine produces the increase of intracellular cAMP content via non-selective inhibition of PDE isozymes, which may be a key mechanism involved in its gastroprotective actions [3].

Product Properties

• Molecular Weight: 372.16
• CAS Number: [84504-69-8]
• Formula: C13H11Cl2N5O4
• Target: mAChR,Phosphodiesterase (PDE)

Application Notes

• Application Notes: MCE Product type: Reference compound