Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 µM. Rutaecarpine can target and activate the NRF2/HO-1 pathway to reduce craniofacial injury. Rutaecarpine sttenuates oxidative stress-induced traumatic brain injury (TBI) and reduces secondary injury via the PGK1/KEAP1/NRF2 signaling pathway. Rutaecarpine can cross the blood-brain barrier (BBB).
Molekulargewicht:
287.32
Reinheit:
99.09
CAS Nummer:
[84-26-4]
Formel:
C18H13N3O
Target-Kategorie:
COX,Keap1-Nrf2
Anwendungsbeschreibung:
MCE Product type: Natural Products
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