Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 µM. Rutaecarpine can target and activate the NRF2/HO-1 pathway to reduce craniofacial injury. Rutaecarpine sttenuates oxidative stress-induced traumatic brain injury (TBI) and reduces secondary injury via the PGK1/KEAP1/NRF2 signaling pathway. Rutaecarpine can cross the blood-brain barrier (BBB).
Molecular Weight:
287.32
Purity:
99.09
CAS Number:
[84-26-4]
Formula:
C18H13N3O
Target:
COX,Keap1-Nrf2
Application Notes:
MCE Product type: Natural Products
* VAT and and shipping costs not included. Errors and price changes excepted