(+)-Columbianetin acts as an inhibitor of JNK and ERK as well as an activator of TGFbeta signaling. (+)-Columbianetin inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced collagen degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS, blocks sub-G1 cell cycle arrest, modulates the expression of MMP, and protects human keratinocytes against UVB-induced damage. (+)-Columbianetin is applicable to research related to skin aging[1][2].
Molekulargewicht:
246.26
Reinheit:
99.04
CAS Nummer:
[3804-70-4]
Formel:
C14H14O4
Target-Kategorie:
ERK,JNK,TGF-beta/Smad
Anwendungsbeschreibung:
MCE Product type: Natural Products
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten