(+)-Columbianetin acts as an inhibitor of JNK and ERK as well as an activator of TGFbeta signaling. (+)-Columbianetin inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced collagen degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS, blocks sub-G1 cell cycle arrest, modulates the expression of MMP, and protects human keratinocytes against UVB-induced damage. (+)-Columbianetin is applicable to research related to skin aging[1][2].
Molecular Weight:
246.26
Purity:
99.04
CAS Number:
[3804-70-4]
Formula:
C14H14O4
Target:
ERK,JNK,TGF-beta/Smad
Application Notes:
MCE Product type: Natural Products
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