Phellodendrine, CAS [[6873-13-8]] Preis auf Anfrage

Produktübersicht

• Artikelname: Phellodendrine, CAS [[6873-13-8]] Preis auf Anfrage
• Artikelnummer: MCE-HY-N0427
• Hersteller Artikelnummer: HY-N0427
• Alternativnummer: MCE-HY-N0427-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

Phellodendrine is an orally active plant alkaloid. Phellodendrine inhibits the proliferation of KRAS-mutated pancreatic cancer cells by suppressing macropinocytosis and glutamine metabolism, inducing ROS accumulation and mitochondrial apoptosis. Phellodendrine promotes autophagy by activating the AMPK/mTOR pathway, alleviating intestinal damage in ulcerative colitis. Phellodendrine can alleviate gouty arthritis by inhibiting the IL-6/STAT3 signaling pathway. Phellodendrine suppresses allergic reactions by altering the conformation of MRGPRB3/MRGPRX2 protein, thereby inhibiting the activation of PKC and subsequent downstream MAPK and NF-kappaB signaling. Phellodendrine inhibits the AKT/NF-kappaB pathway and down-regulates the expression of COX-2, thereby protecting zebrafish embryos from oxidative stress. Phellodendrine has an anti-major depressive disorder (MDD) effect by down-regulating CHRM1, HTR1A, and the PI3K/Akt signaling pathway[1][2][3][4][5][6].

Produkteigenschaften

• Molekulargewicht: 342.41
• Reinheit: 99.60
• CAS Nummer: [6873-13-8]
• Formel: C20H24NO4
• Target-Kategorie: Akt,AMPK,Apoptosis,Autophagy,COX,Interleukin Related,MMP,mTOR,NF-kappaB,p38 MAPK,PI3K,PKC,Reactive Oxygen Species (ROS),STAT

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Natural Products