Phellodendrine, CAS [[6873-13-8]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-N0427
Supplier Catalog Number:
HY-N0427
Alternative Catalog Number:
MCE-HY-N0427-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Phellodendrine is an orally active plant alkaloid. Phellodendrine inhibits the proliferation of KRAS-mutated pancreatic cancer cells by suppressing macropinocytosis and glutamine metabolism, inducing ROS accumulation and mitochondrial apoptosis. Phellodendrine promotes autophagy by activating the AMPK/mTOR pathway, alleviating intestinal damage in ulcerative colitis. Phellodendrine can alleviate gouty arthritis by inhibiting the IL-6/STAT3 signaling pathway. Phellodendrine suppresses allergic reactions by altering the conformation of MRGPRB3/MRGPRX2 protein, thereby inhibiting the activation of PKC and subsequent downstream MAPK and NF-kappaB signaling. Phellodendrine inhibits the AKT/NF-kappaB pathway and down-regulates the expression of COX-2, thereby protecting zebrafish embryos from oxidative stress. Phellodendrine has an anti-major depressive disorder (MDD) effect by down-regulating CHRM1, HTR1A, and the PI3K/Akt signaling pathway[1][2][3][4][5][6].
Molecular Weight:
342.41
Purity:
99.60
CAS Number:
[6873-13-8]
Formula:
C20H24NO4
Target:
Akt,AMPK,Apoptosis,Autophagy,COX,Interleukin Related,MMP,mTOR,NF-kappaB,p38 MAPK,PI3K,PKC,Reactive Oxygen Species (ROS),STAT
Application Notes:
MCE Product type: Natural Products
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