()-Eriodictyol (()-Huazhongilexone, Dihydroluteolin) is an orally active TRPV1 receptor antagonist (IC50=44-47 nM, rTRPV1) with antioxidant and anti-inflammatory activities. ()-Eriodictyol effectively inhibits lipid peroxidation and the release of proinflammatory cytokines by specifically antagonizing the TRPV1 receptor and activating the Nrf2 signaling pathway. ()-Eriodictyol reduces the levels of ICAM-1, VEGF, eNOS and TNF-alpha in the retina and maintains the integrity of the blood-retinal barrier. ()-Eriodictyol alleviates oxidative stress-induced apoptosis and hyperalgesia, enhances the activity and cytotoxicity of immune cells (such as B lymphocytes, NK cells and macrophages), and increases the levels of antioxidant enzymes simultaneously. ()-Eriodictyol can be used in the research of diabetic retinopathy, acute lung injury and various pain-related diseases[1][2][3][4][5].
Molekulargewicht:
288.25
Reinheit:
99.9
CAS Nummer:
[4049-38-1]
Formel:
C15H12O6
Target-Kategorie:
Melanocortin Receptor,TRP Channel
Anwendungsbeschreibung:
MCE Product type: Natural Products
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
