()-Eriodictyol (()-Huazhongilexone, Dihydroluteolin) is an orally active TRPV1 receptor antagonist (IC50=44-47 nM, rTRPV1) with antioxidant and anti-inflammatory activities. ()-Eriodictyol effectively inhibits lipid peroxidation and the release of proinflammatory cytokines by specifically antagonizing the TRPV1 receptor and activating the Nrf2 signaling pathway. ()-Eriodictyol reduces the levels of ICAM-1, VEGF, eNOS and TNF-alpha in the retina and maintains the integrity of the blood-retinal barrier. ()-Eriodictyol alleviates oxidative stress-induced apoptosis and hyperalgesia, enhances the activity and cytotoxicity of immune cells (such as B lymphocytes, NK cells and macrophages), and increases the levels of antioxidant enzymes simultaneously. ()-Eriodictyol can be used in the research of diabetic retinopathy, acute lung injury and various pain-related diseases[1][2][3][4][5].
Molecular Weight:
288.25
Purity:
99.9
CAS Number:
[4049-38-1]
Formula:
C15H12O6
Target:
Melanocortin Receptor,TRP Channel
Application Notes:
MCE Product type: Natural Products
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