Aloin B (Isobarbaloin) is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor with an IC50 of 16.08 µM (hydrolytic activity) and 17.51 µM (deubiquitinase activity). Aloin B is metabolized by rat intestinal flora into aloe-emodin-9-anthrone to exert laxative effects. Aloin B inhibits TPA (HY-18739)-induced ear edema, putrescine elevation, and tumor promotion in mouse skin. Aloin B can be used in research related to anti-inflammation, tumor promotion inhibition, coronavirus disease 2019 (COVID-19) and constipation[1][2][3].
Molekulargewicht:
418.39
Reinheit:
99.87
CAS Nummer:
[28371-16-6]
Formel:
C21H22O9
Target-Kategorie:
SARS-CoV,Virus Protease
Anwendungsbeschreibung:
MCE Product type: Natural Products
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