Aloin B (Isobarbaloin) is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor with an IC50 of 16.08 µM (hydrolytic activity) and 17.51 µM (deubiquitinase activity). Aloin B is metabolized by rat intestinal flora into aloe-emodin-9-anthrone to exert laxative effects. Aloin B inhibits TPA (HY-18739)-induced ear edema, putrescine elevation, and tumor promotion in mouse skin. Aloin B can be used in research related to anti-inflammation, tumor promotion inhibition, coronavirus disease 2019 (COVID-19) and constipation[1][2][3].
Molecular Weight:
418.39
Purity:
99.87
CAS Number:
[28371-16-6]
Formula:
C21H22O9
Target:
SARS-CoV,Virus Protease
Application Notes:
MCE Product type: Natural Products
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