Santamarine (Santamarin, Balchanin) is a sesquiterpene lactone found in Artemisia scoparia. Santamarine shows anti-inflammatory, antioxidant, anticancer and anti-photoaging activities. Santamarine suppresses UVA-induced phosphorylation of JNK and p38 MAPK, nuclear translocation of phosphorylated c-Fos and c-Jun, and AP-1-mediated MMP-1 transcription and secretion. Santamarine suppresses NF-kappaB signaling, iNOS, COX-2, TNF-alpha, and IL-1beta production. Santamarine inhibits thioredoxin reductase activity, induces ROS production, mitochondrial apoptosis, G2/M cell cycle arrest, and DNA damage, and reduces cancer cell growth. Santamarine can be used for the photoaging, inflammatory diseases and cancer[1][2][3][4].
Molekulargewicht:
248.32
Reinheit:
98.85
CAS Nummer:
[4290-13-5]
Formel:
C15H20O3
Target-Kategorie:
Apoptosis,Bcl-2 Family,Caspase,COX,DNA/RNA Synthesis,Interleukin Related,JNK,Keap1-Nrf2,Mitochondrial Metabolism,MMP,NF-kappaB,p38 MAPK,PARP,Reactive Oxygen Species (ROS),TGF-beta/Smad,TNF Receptor
Anwendungsbeschreibung:
MCE Product type: Natural Products
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