Santamarine (Santamarin), a sesquiterpene lactone, increases HO-1 expression through Nrf2 translocation and suppresses NO, PGE2, TNF-alpha, and IL-1beta production through inhibition of NF-kappaB translocation in LPS-induced macrophages. Santamarine shows anti-photoaging properties via inhibition of MAPK/AP-1 and stimulation of TGF-beta/Smad signaling in UVA-irradiated human dermal fibroblasts (HDFs). Antioxidant activities[1][2].
Molecular Weight:
248.32
Purity:
98.85
CAS Number:
[4290-13-5]
Formula:
C15H20O3
Target:
Keap1-Nrf2
Application Notes:
MCE Product type: Natural Products
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