Glycocholic acid hydrate is a bile acid derivative. Glycocholic acid hydrate downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid hydrate inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid hydrate modulates related bile acid receptor signaling. Glycocholic acid hydrate suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid hydrate can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA)[1][2][3].
Reinheit:
97
CAS Nummer:
[1192657-83-2]
Formel:
C26H43NO6.xH2O
Target-Kategorie:
Apoptosis,Bacterial,Bcl-2 Family,Caspase,Endogenous Metabolite,FXR,G protein-coupled Bile Acid Receptor 1,LPL Receptor,MDM-2/p53,P-glycoprotein
Anwendungsbeschreibung:
MCE Product type: Natural Products
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