Polyphyllin H, CAS [[81917-50-2]]

Produktübersicht

• Artikelname: Polyphyllin H, CAS [[81917-50-2]]
• Artikelnummer: MCE-HY-N2382
• Hersteller Artikelnummer: HY-N2382
• Alternativnummer: MCE-HY-N2382-10MMX1ML,MCE-HY-N2382-5MG,MCE-HY-N2382-10MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

Polyphyllin H is a steroidal saponin. Polyphyllin H is isolated from Paris polyphylla. Polyphyllin H potently inhibits the activities of CYP1A2 (IC50 = 6.44 µM, competitive), CYP2D6 (IC50 = 13.88 µM, competitive) and CYP3A4 (IC50 = 4.52 µM, non-competitive, time-dependent). Polyphyllin H downregulates the expression of ABCB1 and ABCC3. Polyphyllin H binds to membrane cholesterol and disrupts lipid raft structures. Polyphyllin H restores the sensitivity of paclitaxel-resistant breast cancer cells to paclitaxel[1][2].

Produkteigenschaften

• Molekulargewicht: 871.02
• Reinheit: 99.89
• CAS Nummer: [81917-50-2]
• Formel: C44H70O17
• Target-Kategorie: Cytochrome P450,P-glycoprotein

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Natural Products