Polyphyllin H is a steroidal saponin. Polyphyllin H is isolated from Paris polyphylla. Polyphyllin H potently inhibits the activities of CYP1A2 (IC50 = 6.44 µM, competitive), CYP2D6 (IC50 = 13.88 µM, competitive) and CYP3A4 (IC50 = 4.52 µM, non-competitive, time-dependent). Polyphyllin H downregulates the expression of ABCB1 and ABCC3. Polyphyllin H binds to membrane cholesterol and disrupts lipid raft structures. Polyphyllin H restores the sensitivity of paclitaxel-resistant breast cancer cells to paclitaxel[1][2].
Molecular Weight:
871.02
Purity:
99.89
CAS Number:
[81917-50-2]
Formula:
C44H70O17
Target:
Cytochrome P450,P-glycoprotein
Application Notes:
MCE Product type: Natural Products
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