Poricoic acid A can be isolated from Poria cocos. Poricoic acid A is an orally active anti-tumor agent. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFkappaB/Nrf2 axis. Poricoic acid A also attenuatea fibroblast activation and abnormal extracellular matrix remodeling in renal fibrosis by activating AMPK and inhibiting Smad3. Poricoic acid A significantly reduces the magnitude of rise in serum creatinine and urea levels in rat model when combined with Melatonin. Poricoic acid A ameliorates renal fibrosis and podocyte injury by attenuating oxidative stress and inflammation through regulating NF-kappaB and Nrf2 in IRI rodent model in combination with Melatonin[1][2][3].
Molekulargewicht:
498.69
Reinheit:
99.66
CAS Nummer:
[137551-38-3]
Formel:
C31H46O5
Target-Kategorie:
AMPK,Keap1-Nrf2,NF-kappaB,Reactive Oxygen Species (ROS),TGF-beta/Smad
Anwendungsbeschreibung:
MCE Product type: Natural Products
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
