Poricoic acid A can be isolated from Poria cocos. Poricoic acid A is an orally active anti-tumor agent. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFkappaB/Nrf2 axis. Poricoic acid A also attenuatea fibroblast activation and abnormal extracellular matrix remodeling in renal fibrosis by activating AMPK and inhibiting Smad3. Poricoic acid A significantly reduces the magnitude of rise in serum creatinine and urea levels in rat model when combined with Melatonin. Poricoic acid A ameliorates renal fibrosis and podocyte injury by attenuating oxidative stress and inflammation through regulating NF-kappaB and Nrf2 in IRI rodent model in combination with Melatonin[1][2][3].
Molecular Weight:
498.69
Purity:
99.66
CAS Number:
[137551-38-3]
Formula:
C31H46O5
Target:
AMPK,Keap1-Nrf2,NF-kappaB,Reactive Oxygen Species (ROS),TGF-beta/Smad
Application Notes:
MCE Product type: Natural Products
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