Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca2+ influx through voltage-gated Ca2+ channels, leading to the reduction in [Ca2+]i in vascular smooth muscle cells and consequent peripheral vasodilation[1]. Yangambin exhibits the antiallergic activity against beta-hexosaminidase release with an IC50 of 33.8 µM and for anti-inflammatory activity with an IC50 of 37.4 µM[2].
Molekulargewicht:
446.49
Reinheit:
98.27
CAS Nummer:
[13060-14-5]
Formel:
C24H30O8
Target-Kategorie:
Calcium Channel
Anwendungsbeschreibung:
MCE Product type: Natural Products
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