Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca2+ influx through voltage-gated Ca2+ channels, leading to the reduction in [Ca2+]i in vascular smooth muscle cells and consequent peripheral vasodilation[1]. Yangambin exhibits the antiallergic activity against beta-hexosaminidase release with an IC50 of 33.8 µM and for anti-inflammatory activity with an IC50 of 37.4 µM[2].
Molecular Weight:
446.49
Purity:
98.27
CAS Number:
[13060-14-5]
Formula:
C24H30O8
Target:
Calcium Channel
Application Notes:
MCE Product type: Natural Products
* VAT and and shipping costs not included. Errors and price changes excepted
